Synthesis and functional studies of self-adjuvanting multicomponent anti-HER2 cancer vaccines.

ABSTRACT: Breast cancer is the leading cause of cancer-related deaths among women worldwide. Human epidermal growth factor receptor 2 (HER2) overexpression is significantly associated with higher breast tumor proliferation rates. MFCH401, a 9-mer specific peptide fragment (DTILWKDIF) in the extracellular domain of the HER2 protein, is an attractive epitope for developing anti-HER2 cancer vaccines. However, the inherent low immunogenicity of MFCH401 limits its application. Herein, to induce a stronger and more durable immune response, a self-adjuvanting MFCH401-conjugated multiple-component anti-HER2 cancer vaccine was designed and synthesized by incorporating MFCH401 with lipopeptide Pam₃CSK₄ and a helper T cell epitope derived from tetanus toxoid P2 via an iterative con

SUBMITTER: Feng Q 

PROVIDER: S-EPMC9042281 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature