The radical scavenging activity of muriolide in physiological environments: mechanistic and kinetic insights into double processes.

ABSTRACT: Muriolide (MO) is a natural lactone that was isolated from Ranunculus muricatus. This compound exhibited good antioxidant activity in some experiments; however, the radical scavenging activity of MO in physiological environments has not been studied yet. In this study, the reaction between hydroperoxyl radical and MO was investigated in physiological environments by using density functional theory (DFT) calculations. It was found that MO exhibits excellent antiradical activity in water at physiological pH (k = 1.05 × 10⁸ M^-1 s^-1) by the single electron transfer mechanism of the anion state. However, the activity in lipid media is moderate with k = 2.54 × 10⁴ M^-1 s^-1 and is defined by the formal hydrogen

SUBMITTER: Hoa NT 

PROVIDER: S-EPMC9042307 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature