Combinatorial design of a sialic acid imprinted binding site exploring a dual ion receptor approach.

ABSTRACT: Aberrant sialic acid expression is one of the key indicators of pathological processes. This acidic saccharide is overexpressed in tumor cells and is a potent biomarker. Development of specific capture tools for various sialylated targets is an important step for early cancer diagnosis. However, sialic acid recognition by synthetic hosts is often complicated due to the competition for the anion binding by their counterions, such as Na⁺ and K⁺. Here we report on the design of a sialic acid receptor via simultaneous recognition of both the anion and cation of the target analyte. The polymeric receptor was produced using neutral (thio)urea and crown ether based monomers for simultaneous complexation of sialic acid's carboxylate group and its countercation. Thioure

SUBMITTER: Mavliutova L 

PROVIDER: S-EPMC9042400 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature