Genome-Wide Identification of Cellular Pathways and Key Genes That Respond to Sodium Bicarbonate Stress in Saccharomyces cerevisiae.

ABSTRACT: Sodium bicarbonate (NaHCO₃) is an important inorganic salt. It is not only widely used in industrial production and daily life, but is also the main stress in alkaline saline soil. NaHCO₃ has a strong ability to inhibit the growth of fungi in both natural environment and daily application. However, the mechanism by which fungi respond to NaHCO₃ stress is not fully understood. To further clarify the toxic mechanisms of NaHCO₃ stress and identify the specific cellular genes and pathways involved in NaHCO₃ resistance, we performed genome-wide screening with NaHCO₃ using a Saccharomyces cerevisiae deletion mutant library. A total of 33 deletion mutants with NaHCO₃ sensitivity were identified. Compared with wild

SUBMITTER: Cao X 

PROVIDER: S-EPMC9042421 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature