Microbial transglutaminase nanoflowers as an alternative nanomedicine for breast cancer theranostics.

ABSTRACT: Breast cancer is the most common malignancy among women. With the aim of decreasing the toxicity of conventional breast cancer treatments, an alternative that could provide appropriate and effective drug utilization was envisioned. Thus, we contemplated and compared the in vitro effects of microbial transglutaminase nanoflowers (MTGase NFs) on breast cancer cells (MCF-7). Transglutaminase is an important regulatory enzyme acting as a site-specific cross-linker for proteins. With the versatility of MTGase facilitating the nanoflower formation by acting as molecular glue, it was demonstrated to have anti-cancer properties. The rational drug design based on a transglutaminase enzyme-assisted approach led to the uniform shape of petals in these nanoflowers, which had the capacity to act

SUBMITTER: Fatima SW 

PROVIDER: S-EPMC9042677 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature