Abrogation of graft ischemia-reperfusion injury in ischemia-free liver transplantation.

ABSTRACT:

Background

Ischemia-reperfusion injury (IRI) is considered an inherent component of organ transplantation that compromises transplant outcomes and organ availability. The ischemia-free liver transplantation (IFLT) procedure has been developed to avoid interruption of blood supply to liver grafts. It is unknown how IFLT might change the characteristics of graft IRI.

Methods

Serum and liver biopsy samples were collected from IFLT and conventional liver transplantation (CLT) recipients. Pathological, metabolomics, transcriptomics, and proteomics analyses were performed to identify the characteristic changes in graft IRI in IFLT.

Results

Peak aspartate aminotransferase (539.59 ± 661.76 U/L versus 2622.28 ± 3291.57 U/L) and alanine aminotransferase (297.64 ± 549.50 U/L ver

SUBMITTER: Guo Z 

PROVIDER: S-EPMC9042797 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature