A preclinical radiotherapy dosimetry audit using a realistic 3D printed murine phantom.

ABSTRACT: Preclinical radiation research lacks standardized dosimetry procedures that provide traceability to a primary standard. Consequently, ensuring accuracy and reproducibility between studies is challenging. Using 3D printed murine phantoms we undertook a dosimetry audit of Xstrahl Small Animal Radiation Research Platforms (SARRPs) installed at 7 UK centres. The geometrically realistic phantom accommodated alanine pellets and Gafchromic EBT3 film for simultaneous measurement of the dose delivered and the dose distribution within a 2D plane, respectively. Two irradiation scenarios were developed: (1) a 10 × 10 mm² static field targeting the pelvis, and (2) a 5 × 5 mm² 90° arc targeting the brain. For static fields, the absolute difference between the planned dose and alani

SUBMITTER: Biglin ER 

PROVIDER: S-EPMC9042835 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature