Development and external validation of a prediction model for overall survival after resection of distal cholangiocarcinoma.

ABSTRACT:

Background

Various prognostic factors are associated with overall survival (OS) after resection of distal cholangiocarcinoma (dCCA). The objective of this study was to develop and validate a prediction model for 3-year OS after pancreatoduodenectomy for dCCA.

Methods

The derivation cohort consisted of all patients who underwent pancreatoduodenectomy for dCCA in the Netherlands (2009-2016). Clinically relevant variables were selected based on the Akaike information criterion using a multivariate Cox proportional hazards regression model, with model performance being assessed by concordance index (C-index) and calibration plots. External validation was performed using patients from the Belgium Cancer Registry (2008-2016), and patients from two university hospitals of Southampt

SUBMITTER: Belkouz A 

PROVIDER: S-EPMC9042862 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature