Mechanistic insights into encapsulation and release of drugs in colloidal niosomal systems: biophysical aspects.

ABSTRACT: Vesicular systems such as niosomes provide an alternative to improve drug delivery systems. The efficiency of a drug delivery vehicle is strongly dependent on its components which decide its interaction with partitioned drug(s) and locus of site of partitioning. A quantitative understanding of the physical chemistry underlying partitioning of drugs in complex systems of self-assemblies such as niosomes is scarcely available. In order to obtain quantitative mechanistic insights into partitioning and release of drugs [mitoxantrone (MTX) and ketoprofen (KTP)] in systems of niosomes, we have employed ultrasensitive calorimetry, spectroscopy and microscopy to establish correlations between functionality and energetics which could provide guidance towards rational drug design and choice of suita

SUBMITTER: Judy E 

PROVIDER: S-EPMC9042874 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature