Integrative analysis of TCGA data identifies miRNAs as drug-specific survival biomarkers.

ABSTRACT: Biomarkers predictive of drug-specific outcomes are important tools for personalized medicine. In this study, we present an integrative analysis to identify miRNAs that are predictive of drug-specific survival outcome in cancer. Using the clinical data from TCGA, we defined subsets of cancer patients who suffered from the same cancer and received the same drug treatment, which we call cancer-drug groups. We then used the miRNA expression data in TCGA to evaluate each miRNA's ability to predict the survival outcome of patients in each cancer-drug group. As a result, the identified miRNAs are predictive of survival outcomes in a cancer-specific and drug-specific manner. Notably, most of the drug-specific miRNA survival markers and their target genes showed consistency in terms of correlation

SUBMITTER: Lin S 

PROVIDER: S-EPMC9042876 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature