A systematic review of microbial markers for risk prediction of colorectal neoplasia.

ABSTRACT:

Background

Substantial evidence indicates that dysbiosis of the gut microbial community is associated with colorectal neoplasia. This review aims to systematically summarise the microbial markers associated with colorectal neoplasia and to assess their predictive performance.

Methods

A comprehensive literature search of MEDLINE and EMBASE databases was performed to identify eligible studies. Observational studies exploring the associations between microbial biomarkers and colorectal neoplasia were included. We also included prediction studies that constructed models using microbial markers to predict CRC and adenomas. Risk of bias for included observational and prediction studies was assessed.

Results

Forty-five studies were included to assess the associations between

SUBMITTER: Yu L 

PROVIDER: S-EPMC9042911 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature