T cell receptor and IL-2 signaling strength control memory CD8⁺ T cell functional fitness via chromatin remodeling.

ABSTRACT: Cognate antigen signal controls CD8⁺ T cell priming, expansion size and effector versus memory cell fates, but it is not known if and how it modulates the functional features of memory CD8⁺ T cells. Here we show that the strength of T cell receptor (TCR) signaling controls the requirement for interleukin-2 (IL-2) signals to form a pool of memory CD8⁺ T cells that competitively re-expand upon secondary antigen encounter. Combining strong TCR and intact IL-2 signaling during priming synergistically induces genome-wide chromatin accessibility in regions targeting a wide breadth of biological processes, consistent with greater T cell functional fitness. Chromatin accessibility in promoters of genes encoding for stem cell, cell cycle and calcium-related proteins

SUBMITTER: Chin SS 

PROVIDER: S-EPMC9042912 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature