Mesoscopic landscape of cortical functions revealed by through-skull wide-field optical imaging in marmoset monkeys.

ABSTRACT: The primate cerebral cortex is organized into specialized areas representing different modalities and functions along a continuous surface. The functional maps across the cortex, however, are often investigated a single modality at a time (e.g., audition or vision). To advance our understanding of the complex landscape of primate cortical functions, here we develop a polarization-gated wide-field optical imaging method for measuring cortical functions through the un-thinned intact skull in awake marmoset monkeys (Callithrix jacchus), a primate species featuring a smooth cortex. Using this method, adjacent auditory, visual, and somatosensory cortices are noninvasively parcellated in individual subjects with detailed tonotopy, retinotopy, and somatotopy. An additional pure-tone-responsive to

SUBMITTER: Song X 

PROVIDER: S-EPMC9042927 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature