Role of lncSLCO1C1 in gastric cancer progression and resistance to oxaliplatin therapy.

ABSTRACT:

Background

Gastric carcinoma (GC) is one of the most deadly diseases due to tumour metastasis and resistance to therapy. Understanding the molecular mechanism of tumour progression and drug resistance will improve therapeutic efficacy and develop novel intervention strategies.

Methods

Differentially expressed long non-coding RNAs (lncRNAs) in clinical specimens were identified by LncRNA microarrays and validated in different clinical cohorts by quantitative real-time polymerase chain reaction (qRT-PCR), in situ hybridisation and bioinformatics analysis. Biological functions of lncRNA were investigated by using cell proliferation assays, migration assays, xenograft tumour models and bioinformatics analysis. Effects of lncSLCO1C1 on GC cell survival were assessed by comet assa

SUBMITTER: Xiao YF 

PROVIDER: S-EPMC9043116 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature