Clinical and transcriptomic features of persistent exacerbation-prone severe asthma in U-BIOPRED cohort.

ABSTRACT:

Background

Exacerbation-prone asthma is a feature of severe disease. However, the basis for its persistency remains unclear.

Objectives

To determine the clinical and transcriptomic features of frequent exacerbators (FEs) and persistent FEs (PFEs) in the U-BIOPRED cohort.

Methods

We compared features of FE (≥2 exacerbations in past year) to infrequent exacerbators (IE, <2 exacerbations) and of PFE with repeat ≥2 exacerbations during the following year to persistent IE (PIE). Transcriptomic data in blood, bronchial and nasal epithelial brushings, bronchial biopsies and sputum cells were analysed by gene set variation analysis for 103 gene signatures.

Results

Of 317 patients, 62.4% had FE, of whom 63.6% had PFE, while 37.6% had IE, of whom 61.3% had PIE. Using mul

SUBMITTER: Hoda U 

PROVIDER: S-EPMC9043117 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature