Prognostic implications of adaptive immune features in MMR-proficient colorectal liver metastases classified by histopathological growth patterns.

ABSTRACT:

Background

After resection, colorectal cancer liver metastases (CRLM) surrounded by a desmoplastic rim carry a better prognosis than the metastases replacing the adjacent liver. However, these histopathological growth patterns (HGPs) are insufficient to guide clinical decision-making. We explored whether the adaptive immune features of HGPs could refine prognostication.

Methods

From 276 metastases resected in 176 patients classified by HGPs, tissue microarrays were used to assess intratumoral T cells (CD3), antigen presentation capacity (MHC class I) and CD73 expression producing immunosuppressive adenosine. We tested correlations between these variables and patient outcomes.

Results

The 101 (57.4%) patients with dominant desmoplastic HGP had a median recurrence-free

SUBMITTER: Messaoudi N 

PROVIDER: S-EPMC9043179 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature