Rheological characterization of poly-dimethyl siloxane formulations with tunable viscoelastic properties.

ABSTRACT: Studies from the past two decades have demonstrated convincingly that cells are able to sense the mechanical properties of their surroundings. Cells make major decisions in response to this mechanosensation, including decisions regarding cell migration, proliferation, survival, and differentiation. The vast majority of these studies have focused on the cellular mechanoresponse to changing substrate stiffness (or elastic modulus) and have been conducted on purely elastic substrates. In contrast, most soft tissues in the human body exhibit viscoelastic behavior; that is, they generate responsive force proportional to both the magnitude and rate of strain. While several recent studies have demonstrated that viscous effects of an underlying substrate affect cellular mechanoresponse, there is n

SUBMITTER: Petet TJ 

PROVIDER: S-EPMC9043277 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature