Understanding the Genetic Diversity of Mycobacterium africanum Using Phylogenetics and Population Genomics Approaches.

ABSTRACT: A total of two lineages of Mycobacterium tuberculosis var. africanum (Maf), L5 and L6, which are members of the Mycobacterium tuberculosis complex (MTBC), are responsible for causing tuberculosis in West Africa. Regions of difference (RDs) are usually used for delineation of MTBC. With increased data availability, single nucleotide polymorphisms (SNPs) promise to provide better resolution. Publicly available 380 Maf samples were analyzed for identification of "core-cluster-specific-SNPs," while additional 270 samples were used for validation. RD-based methods were used for lineage-assignment, wherein 31 samples remained unidentified. The genetic diversity of Maf was estimated based on genome-wide SNPs using phylogeny and population genomics

SUBMITTER: Balamurugan M 

PROVIDER: S-EPMC9043288 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature