Effect of scar and pacing location on repolarization in a porcine myocardial infarction model.

ABSTRACT:

Background

The effect of chronic ischemic scar on repolarization is unclear, with conflicting results from human and animal studies. An improved understanding of electrical remodeling within scar and border zone tissue may enhance substrate-guided ablation techniques for treatment of ventricular tachycardia. Computational modeling studies have suggested increased dispersion of repolarization during epicardial, but not endocardial, left ventricular pacing, in close proximity to scar. However, the effect of endocardial pacing near scar in vivo is unknown.

Objective

The purpose of this study was to investigate the effect of scar and pacing location on local repolarization in a porcine myocardial infarction model.

Methods

Six model pigs underwent late gadolinium en

SUBMITTER: Elliott MK 

PROVIDER: S-EPMC9043407 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature