Identifying the specific-targeted marine cerebrosides against SARS-CoV-2: an integrated computational approach.

ABSTRACT: Cerebrosides are a group of metabolites belonging to the glycosphingolipids class of natural products. So far, 167 cerebrosides, compounds 1-167, have been isolated from diverse marine organisms or microorganisms. The as yet smaller number of compounds that have been studied more in depth proves a potential against challenging diseases, such as cancer, a range of viral and bacterial diseases, as well as inflammation. This review provides a comprehensive summary on this so far under-explored class of compounds, their chemical structures, bioactivities, and their marine sources, with a full coverage to the end of 2020. Today, the global pandemic concern, COVID-19, has claimed millions of death cases around the world, making the development of anti-SARS-CoV-2 drugs urgently needed for such a

SUBMITTER: Zahran EM 

PROVIDER: S-EPMC9043436 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature