Relationship Between Circulating MicroRNAs and Left Ventricular Hypertrophy in Hypertensive Patients.

ABSTRACT:

Objective

Left ventricular hypertrophy (LVH) is a common complication of hypertension and microRNAs (miRNAs) are considered to play an important role in cardiac hypertrophy development. This study evaluated the relationship between circulating miRNAs and LVH in hypertensive patients.

Methods

Two cohorts [exploratory (n = 42) and validation (n = 297)] of hypertensive patients were evaluated by clinical, laboratory and echocardiography analysis. The serum expression of 754 miRNAs in the exploratory cohort and 6 miRNAs in the validation cohort was evaluated by the TaqMan OpenArray^® system and quantitative polymerase chain reaction, respectively.

Results

Among the 754 analyzed miRNAs, ten miRNAs (miR-30a-5p, miR-let7c, miR-92a, miR-451, miR-145-5p

SUBMITTER: Lopes ECP 

PROVIDER: S-EPMC9043518 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature