Application of an Accessible Interface for Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation.

ABSTRACT: Regulatory toxicology testing has traditionally relied on in vivo methods to inform decision-making. However, scientific, practical, and ethical considerations have led to an increased interest in the use of in vitro and in silico methods to fill data gaps. While in vitro experiments have the advantage of rapid application across large chemical sets, interpretation of data coming from these non-animal methods can be challenging due to the mechanistic nature of many assays. In vitro to in vivo extrapolation (IVIVE) has emerged as a computational tool to help facilitate this task. Specifically, IVIVE uses physiologically based pharmacokinetic (PBPK) models to estimate tissue-level chemical concentrations based on various dosing parameters. This approach is

SUBMITTER: Hines DE 

PROVIDER: S-EPMC9043603 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature