A dual-function phage regulator controls the response of cohabiting phage elements via regulation of the bacterial SOS response.

ABSTRACT: Listeria monocytogenes strain 10403S harbors two phage elements in its chromosome; one produces infective virions and the other tailocins. It was previously demonstrated that induction of the two elements is coordinated, as they are regulated by the same anti-repressor. In this study, we identified AriS as another phage regulator that controls the two elements, bearing the capacity to inhibit their lytic induction under SOS conditions. AriS is a two-domain protein that possesses two distinct activities, one regulating the genes of its encoding phage and the other downregulating the bacterial SOS response. While the first activity associates with the AriS N-terminal AntA/AntB domain, the second associates with its C-terminal ANT/KilAC domain. The ANT/KilAC domain is conserved in many AriS-l

SUBMITTER: Azulay G 

PROVIDER: S-EPMC9043618 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature