Quantification of brain age using high-resolution 7 tesla MR imaging and implications for patients with epilepsy.

ABSTRACT:

Purpose

Epilepsy patients exhibit morphological differences on neuroimaging compared to age-matched healthy controls, including cortical and sub-cortical volume loss and altered gray-white matter ratios. The objective was to develop a model of normal aging using the 7T MRIs of healthy controls. This model can then be used to determine if the changes in epilepsy patients resemble the changes seen in aging, and potentially give a marker for the severity of those changes.

Methods

Sixty-nine healthy controls (24F/45M, mean age 36.5 ± 10.5 years) and forty-four epilepsy patients (24F/20M, 33.2 ± 9.9 years) non-lesional at 3T were scanned with volumetric T1-MPRAGE at 7T. These images were segmented and quantified using FreeSurfer. A linear regression-based model trained on healthy

SUBMITTER: Verma G 

PROVIDER: S-EPMC9043661 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature