Psoriasis and adverse pregnancy outcomes: A nationwide case-control study in 491,274 women in Denmark.

ABSTRACT:

Background

The chronic systemic inflammation associated with psoriasis supposedly creates an undesirable milieu for a pregnancy, resulting in an increased risk of adverse pregnancy outcomes (APOs).

Objective

To investigate the association between psoriasis and APOs as well as how the association differs according to psoriasis severity (mild and moderate-to-severe).

Methods

This nationwide register-based case-control study collected data from 1973 to 2017. Cases were APOs (spontaneous abortion, ectopic pregnancy [EP], intrauterine fetal death, and stillbirth). Singleton live births were controls. Adjusted logistic regression models were used for statistical analyses.

Results

In total, 42,041 (8.56%) APOs and 449,233 (91.44%) controls were included. EP was the on

SUBMITTER: Johansen CB 

PROVIDER: S-EPMC9043664 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature