The effect of excipient particle size on the reduction of compactibility after roller compaction.

ABSTRACT: Developing a robust roller compaction process can be challenging, due to the diversity in process parameters and material properties of the components in a formulation. A major challenge in dry granulation is the reduction of tablet strength as a result of re-compaction of the materials. The aim of this study is to investigate the impact of excipient type and particle size distribution on tablet tensile strength after roller compaction. Lactose monohydrate, anhydrous lactose and microcrystalline cellulose with different particle sizes are roller compacted at varying specific compaction forces. Granules obtained are compressed into tablets to evaluate the reduction in tablet strength upon increasing the specific compaction force. The impact of particle size of the starting material is shown

SUBMITTER: Janssen PHM 

PROVIDER: S-EPMC9043665 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature