A Sequence Obfuscation Method for Protecting Personal Genomic Privacy.

ABSTRACT: With the technological advances in recent decades, determining whole genome sequencing of a person has become feasible and affordable. As a result, large-scale individual genomic sequences are produced and collected for genetic medical diagnoses and cancer drug discovery, which, however, simultaneously poses serious challenges to the protection of personal genomic privacy. It is highly urgent to develop methods which make the personal genomic data both utilizable and confidential. Existing genomic privacy-protection methods are either time-consuming for encryption or with low accuracy of data recovery. To tackle these problems, this paper proposes a sequence similarity-based obfuscation method, namely IterMegaBLAST, for fast and reliable protection of personal genomic privacy. Specifically

SUBMITTER: Wan S 

PROVIDER: S-EPMC9043694 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature