Spinal fixation after laminectomy in pigs prevents postoperative spinal cord injury.

ABSTRACT:

Background

A safe, effective, and ethically sound animal model is essential for preclinical research to investigate spinal medical devices. We report the initial failure of a porcine spinal survival model and a potential solution by fixating the spine.

Methods

Eleven female Dutch Landrace pigs underwent a spinal lumbar interlaminar decompression with durotomy and were randomized for implantation of a medical device or control group. Magnetic resonance imaging (MRI) was performed before termination.

Results

Neurological deficits were observed in 6 out of the first 8 animals. Three of these animals were terminated prematurely because they reached the predefined humane endpoint. Spinal cord compression and myelopathy was observed on postoperative MRI imaging. We hypothes

SUBMITTER: Slot EMH 

PROVIDER: S-EPMC9043715 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature