Machine Learning Models for Diagnosis of Parkinson's Disease Using Multiple Structural Magnetic Resonance Imaging Features.

ABSTRACT:

Purpose

This study aimed to develop machine learning models for the diagnosis of Parkinson's disease (PD) using multiple structural magnetic resonance imaging (MRI) features and validate their performance.

Methods

Brain structural MRI scans of 60 patients with PD and 56 normal controls (NCs) were enrolled as development dataset and 69 patients with PD and 71 NCs from Parkinson's Progression Markers Initiative (PPMI) dataset as independent test dataset. First, multiple structural MRI features were extracted from cerebellar, subcortical, and cortical regions of the brain. Then, the Pearson's correlation test and least absolute shrinkage and selection operator (LASSO) regression were used to select the most discriminating features. Finally, using logistic regression (LR) classi

SUBMITTER: Ya Y 

PROVIDER: S-EPMC9043762 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature