Ontology highlight
ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC9043764 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Yang Lewei L Zeng Qi Q Deng Yun Y Qiu Yeqing Y Yao Wei W Liao Yifeng Y
Frontiers in oncology 20220413
Dysregulation of cysteine cathepsin protease activity is pivotal in tumorigenic transformation. However, the role of cathepsin protease in lung cancer remains unknown. Here, we analyzed GEO database and found that lung cancer presented high expression of cathepsin V (<i>CTSV</i>). We then performed immunohistochemistry assay in 73 paired lung cancer tissues and normal lung tissues and confirmed that <i>CTSV</i> is overexpressed in lung cancer and correlates with poor prognosis. The mass spectrom ...[more]