C(acyl)-C(sp²) and C(sp²)-C(sp²) Suzuki-Miyaura cross-coupling reactions using nitrile-functionalized NHC palladium complexes.

ABSTRACT: Application of N-heterocyclic carbene (NHC) palladium complexes has been successful for the modulation of C-C coupling reactions. For this purpose, a series of azolium salts (1a-f) including benzothiazolium, benzimidazolium, and imidazolium, bearing a CN-substituted benzyl moiety, and their (NHC)₂PdBr₂ (2a-c) and PEPPSI-type palladium (3b-f) complexes have been systematically prepared to catalyse acylative Suzuki-Miyaura coupling reaction of acyl chlorides with arylboronic acids to form benzophenone derivatives in the presence of potassium carbonate as a base and to catalyse the traditional Suzuki-Miyaura coupling reaction of bromobenzene with arylboronic acids to form biaryls. All the synthesized compounds were fully characterized by Fourier Transform Infrared (FTIR)

SUBMITTER: Cakır S 

PROVIDER: S-EPMC9043785 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature