Unknown

Dataset Information

0

Acetonitrile and benzonitrile as versatile amino sources in copper-catalyzed mild electrochemical C-H amidation reactions.


ABSTRACT: A mild, efficient electrochemical approach to the site-selective direct C-H amidation of benzene and its derivatives with acetonitrile and benzonitrile has been developed. It has been shown that joint electrochemical oxidation of various arenes in the presence of a copper salt as a catalyst and nitriles leads to the formation of N-phenylacetamide from benzene and N-benzylacetamides from benzyl derivatives (up to 78% yield). A favorable feature of the process is mild conditions (room temperature, ambient pressure, no strong oxidants) that meet the criteria of green chemistry.

SUBMITTER: Strekalova S 

PROVIDER: S-EPMC9043791 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Acetonitrile and benzonitrile as versatile amino sources in copper-catalyzed mild electrochemical C-H amidation reactions.

Strekalova Sofia S   Kononov Alexander A   Rizvanov Ildar I   Budnikova Yulia Y  

RSC advances 20211122 59


A mild, efficient electrochemical approach to the site-selective direct C-H amidation of benzene and its derivatives with acetonitrile and benzonitrile has been developed. It has been shown that joint electrochemical oxidation of various arenes in the presence of a copper salt as a catalyst and nitriles leads to the formation of <i>N</i>-phenylacetamide from benzene and <i>N</i>-benzylacetamides from benzyl derivatives (up to 78% yield). A favorable feature of the process is mild conditions (roo  ...[more]

Similar Datasets

| S-EPMC8457245 | biostudies-literature
| S-EPMC3985719 | biostudies-literature
| S-EPMC5080986 | biostudies-literature
| S-EPMC6713870 | biostudies-literature
| S-EPMC9894310 | biostudies-literature
| S-EPMC11922052 | biostudies-literature
| S-EPMC10310717 | biostudies-literature
| S-EPMC9698776 | biostudies-literature
| S-EPMC3872066 | biostudies-literature
| S-EPMC2826166 | biostudies-literature