Solvothermal synthesis of Nb-doped TiO₂ nanoparticles with enhanced sonodynamic effects for destroying tumors.

ABSTRACT: Titania (TiO₂) nanomaterials have been proved to be biocompatible sonosensitizers for sonodynamic therapy (SDT) of various cancer cells, while they suffer from weak sonodynamic effects due to fast combination of excited carriers. In this work, to improve the therapeutic efficiency, we prepared PEGylated Nb-doped TiO₂ (TiO_2-x :Nb) nanoparticles by a simple solvothermal method and a subsequent surface modification process. The TiO_2-x :Nb nanoparticles exhibited an average size of 11 nm and a polydisperse index of 0.12. The Nb doping had no obvious effect on the phase of TiO₂ matrixes but released electrons to the conduction band of TiO₂, resulting in high concentrations of deficiencies. As a result, the TiO₂

SUBMITTER: Sun W 

PROVIDER: S-EPMC9043821 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature