Comparison of drug release behavior of bacterial cellulose loaded with ibuprofen and propranolol hydrochloride.

ABSTRACT: The aim of this study was to investigate the drug release behavior from bacterial cellulose (BC). Ibuprofen and propranolol hydrochloride were used as model drugs to represent low and highly water soluble drugs. The drug was loaded into the BC by immersing the partially swollen BC in a solution of drug concentrations ranging from 0.05 to 0.5 mg mL^-1 and then drying by two different methods: air-drying and freeze-drying. The results showed that the type of drug and the drying method influenced the drug loading efficiency and drug release behavior. For ibuprofen, high drug loading efficiency was found when loading the drug into BC at low concentration and vice versa for propranolol hydrochloride. The drug-loaded BC prepared by the freeze-drying method showed a sustained rel

SUBMITTER: Jantarat C 

PROVIDER: S-EPMC9043831 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature