Hepatitis B infection is causally associated with extrahepatic cancers: A Mendelian randomization study.

ABSTRACT:

Background

Evidence from observational studies suggests that chronic hepatitis B virus (HBV) infection is associated with extrahepatic cancers. However, the causal association between chronic HBV infection and extrahepatic cancers remains to be determined.

Methods

We performed two-sample Mendelian randomization (MR) to investigate whether chronic HBV infection is causally associated with extrahepatic cancers. We identified four independent genetic variants strongly associated (P-value < 5 × 10^-8) with the exposure, chronic HBV infection in 1371 cases and 2938 controls of East Asian ancestry in Korea, which were used as instrumental variables. Genome-wide association summary level data for outcome variables, that included cancer of the biliary tract, cervix, colore

SUBMITTER: Kamiza AB 

PROVIDER: S-EPMC9043966 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature