Transcript levels in plasma contribute substantial predictive value as potential Alzheimer's disease biomarkers in African Americans.

ABSTRACT:

Background

African Americans (AA) remain underrepresented in Alzheimer's disease (AD) research, despite the prevalence of AD being double in AA compared to non-Hispanic whites. To address this disparity, our group has established the Florida Consortium for African American Alzheimer's Disease Studies (FCA³DS), focusing on the identification of genetic risk factors and novel plasma biomarkers.

Method

Utilizing FCA³DS whole exome sequence (WES) and plasma RNA samples from AD cases (n=151) and cognitively unimpaired (CU) elderly controls (n=269), we have performed differential gene expression (DGE) and expression quantitative trait locus (eQTL) analyses on 50 transcripts measured with a custom nanoString® panel. We designed this panel to measure, in plasma

SUBMITTER: Reddy JS 

PROVIDER: S-EPMC9044003 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature