Treatment With Diflunisal in Domino Liver Transplant Recipients With Acquired Amyloid Neuropathy.

ABSTRACT: Objectives: To analyze the efficacy and tolerability of diflunisal for the treatment of acquired amyloid neuropathy in domino liver transplant recipients. Methods: We performed a retrospective longitudinal study of prospectively collected data for all domino liver transplant recipients with acquired amyloid neuropathy who received diflunisal at our hospital. Neurological deterioration was defined as an score increase of ≥2 points from baseline on the Neurological Impairment Scale/Neurological Impairment Scale-Lower Limbs. Results: Twelve patients who had received compassionate use treatment with diflunisal were identified, of whom seven had follow-up data for ≥12 months. Five patients (71.4%) presented with neurological deterioration on the Neurological Impairment Scal

SUBMITTER: Nedkova-Hristova V 

PROVIDER: S-EPMC9044119 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature