Scalable synthesis of favipiravir via conventional and continuous flow chemistry.

ABSTRACT: Decagram scale synthesis of favipiravir was performed in 9 steps using diethyl malonate as cheap starting material. Hydrogenation and bromination steps were achieved by employing a continuous flow reactor. The synthetic process provided a total of 16% yield and it is suitable for larger-scale synthesis and production.

SUBMITTER: Tiyasakulchai T 

PROVIDER: S-EPMC9044180 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature