Unravelling the anticancer potential of a square planar copper complex: toward non-platinum chemotherapy.

ABSTRACT: Coordination compounds from simple transition metals are robust substitutes for platinum-based complexes due to their remarkable anticancer properties. In a quest to find new metal complexes that could substitute or augment the platinum based chemotherapy we synthesized three transition metal complexes C1-C3 with Cu(ii), Ni(ii), and Co(ii) as the central metal ions, respectively, and evaluated them for their anticancer activity against the human keratinocyte (HaCaT) cell line and human cervical cancer (HeLa) cell lines. These complexes showed different activity profiles with the square planar copper complex C1 being the most active with IC₅₀ values lower than those of the widely used anticancer drug cisplatin. Assessment of the morphological changes by DAPI staining and ROS gene

SUBMITTER: Malik MA 

PROVIDER: S-EPMC9044439 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature