Enhanced antimicrobial treatment by a clay-based drug nanocarrier conjugated to a guanidine-rich cell penetrating peptide.

ABSTRACT: In this study, a novel and efficient drug delivery system is proposed for the enhancement of antimicrobial properties of antibiotic medications such as vancomycin (VCM) and levofloxacin (OFX). The architecture of the designed drug carrier is based on halloysite nanotubes (HNTs) with a rolled-laminate shape, suitable for the encapsulation of drug and further release. In order to make them capable for magnetic direction to the target tissue, the exterior surface of the tubes is composed of iron oxide nanoparticles (Fe₃O₄ NPs), via an in situ process. The main role in the antimicrobial activity enhancement is played by a cell-penetrating peptide (CPP) sequence synthesized in the solid phase, which contains three arginine-tryptophan blocks plus a cysteine as

SUBMITTER: Khodabakhshi MR 

PROVIDER: S-EPMC9044475 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature