New 1H-benzimidazole-2-yl hydrazones with combined antiparasitic and antioxidant activity.

ABSTRACT: Parasitic infections, caused mainly by the species Trichinella spiralis (T. spiralis), are widespread around the world and lead to morbidity and mortality in the population. Meanwhile, some studies have showed that these parasites induce oxidative stress in the infected host. With the aim of developing a class of compounds combining anthelmintic with antioxidant properties, a series of new benzimidazolyl-2-hydrazones 5a-l, bearing hydroxyl- and methoxy-groups, were synthesized. The anthelmintic activity on encapsulated T. spiralis was studied in vitro thus indicating that all hydrazones were more active than the clinically used anthelmintic drugs albendazole and ivermectin. 5b and 5d killed the total parasitic larvae (100% effectiveness) after 24 hours incubatio

SUBMITTER: Argirova MA 

PROVIDER: S-EPMC9044521 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature