Synthesis, crystal structures, DNA interactions, and antitumor activity of two new dinuclear copper(ii) complexes with thiazole ligand.

ABSTRACT: Two new dinuclear copper(ii) complexes, [Cu(ambt)₂(cnba)₄] (1) and [Cu(ambt)₂(clba)₄] (2) were synthesized with 2-amino-6-methoxybenzothiazole (ambt) as the main ligand. The structures of the two complexes were characterized by single-crystal XRD. The binding between CT-DNA (calf thymus DNA) and the complexes was evaluated by viscometry, electronic absorption, and fluorescence spectroscopy, and the binding constants were calculated using the Stern-Volmer equation. The complexes were intercalatively bound to CT-DNA, and [Cu(ambt)₂(clba)₄] having a greater binding constant than [Cu(ambt)₂(cnba)₄]. The two complexes had better antitumor properties against HepG2 (human hepatocellular carcinoma), A549 (human

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC9044605 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature