Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β.

ABSTRACT:

Background

The main causes of lung cancer are smoking, environmental pollution and genetic susceptibility. It is an indisputable fact that PAHs are related to lung cancer, and benzo(a) pyrene is a representative of PAHs. The purpose of the current investigation was to investigate the interaction between AhR and HIF-1 signaling pathways in A549 cells, which provide some experimental basis for scientists to find drugs that block AhR and HIF-1 signaling pathway to prevent and treat cancer.

Methods

This project adopts the CYP1A1 signaling pathways and the expression of CYP1B1 is expressed as a measure of AhR strength index. The expression of VEGF and CAIX volume as a measure of the strength of the signal path HIF-1 indicators. Through the construction of plasmid vector, fluoresc

SUBMITTER: Zhang M 

PROVIDER: S-EPMC9044668 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature