The role of ATP-binding cassette subfamily A in the etiology of Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is the leading cause of dementia, clinically characterized by memory deficits and progressive cognitive decline. Despite decades of research effective therapies are lacking, and a large part of the genetic heritability remains unidentified. ABCA7 and ABCA1, members of the ATP-binding cassette subfamily A (ABCA), were identified as AD risk genes in genome-wide association studies. Nevertheless, genetic and/or functional studies propose a link between AD and two other members of the ABCA subclass, i.e., ABCA2 and ABCA5.

Main body

Changes in expression or dysfunction of these transporters were found to increase amyloid β levels. This might be related to the common role of ABCA transporters in cellular cholesterol homeostasis, for which a prom

SUBMITTER: Bossaerts L 

PROVIDER: S-EPMC9044696 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature