Effect of midazolam on delirium in critically ill patients: a propensity score analysis.

ABSTRACT:

Objective

To observe the association between exposure to midazolam within 24 hours prior to delirium assessment and the risk of delirium.

Methods

We performed a systematic cohort study with two sets of cohorts to estimate the relative risks of outcomes among patients administered midazolam within 24 hours prior to delirium assessment. Propensity score matching was performed to generate a balanced 1:1 matched cohort and identify potential prognostic factors. The outcomes included the odds of delirium, mortality, length of intensive care unit stay, length of hospitalization, and odds of being discharged home.

Results

A total of 78,364 patients were included in this study, of whom 22,159 (28.28%) had positive records. Propensity matching successfully balanced covariates

SUBMITTER: Shi HJ 

PROVIDER: S-EPMC9044793 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature