Deletion of TRIB3 disrupts the tumor progression induced by integrin αvβ3 in lung cancer.

ABSTRACT:

Background

Integrin αvβ3 has been proposed as crucial determinant for tumor sustained progression and a molecular marker for the estimation of tumor angiogenesis. Our study suggested that integrin αvβ3 could efficiently promote lung cancer cell proliferation and stem-like phenotypes in a tribbles homolog 3 (TRIB3) dependent manner.

Result

Integrin αvβ3 could mediate the activation of FAK/AKT pro-survival signaling pathway. Meanwhile, activated TRIB3 interacted with AKT to upregulated FOXO1 and SOX2 expression, resulting in sustained tumor progression in lung cancer. Our further analysis revealed that TRIB3 was significantly upregulated in lung tumor tissues and correlated with the poor outcome in clinical patients, indicating the potential role of TRIB3 in diagnostic and pro

SUBMITTER: Zhou W 

PROVIDER: S-EPMC9044834 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature