Weak Expression of Terminal Complement in Active Antibody-Mediated Rejection of the Kidney.

ABSTRACT:

Background

The role of the complement system in antibody-mediated rejection (ABMR) is insufficiently understood. We aimed to investigate the role of local and systemic complement activation in active (aABMR). We quantified complement activation markers, C3, C3d, and C5b-9 in plasma of aABMR, and acute T-cell mediated rejection (aTCMR), and non-rejection kidney transplant recipients. Intra-renal complement markers were analyzed as C4d, C3d, C5b-9, and CD59 deposition. We examined in vitro complement activation and CD59 expression on renal endothelial cells upon incubation with human leukocyte antigen antibodies.

Methods

We included 50 kidney transplant recipients, who we histopathologically classified as aABMR (n=17), aTCMR (n=18), and non-rejection patients (n=15).

SUBMITTER: Tiller G 

PROVIDER: S-EPMC9044906 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature