Ovarian granulosa cells from women with PCOS express low levels of SARS-CoV-2 receptors and co-factors.

ABSTRACT:

Purpose

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is global pandemic with more than 5 million deaths so far. Female reproductive tract organs express coronavirus-associated receptors and factors (SCARFs), suggesting they may be susceptible to SARS-CoV-2 infection; however, the susceptibility of ovary/follicle/oocyte to the same is still elusive. Co-morbidities like obesity, type-2 diabetes mellitus, cardiovascular disease, etc. increase the risk of SARS-CoV-2 infection. These features are common in women with polycystic ovary syndrome (PCOS), warranting further scope to study SCARFs expression in ovary of these women.

Materials and methods

SCARFs expression in ovary and ovarian tissues of women with PCOS and healthy women was explored by analyzin

SUBMITTER: Naigaonkar A 

PROVIDER: S-EPMC9045021 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature