Association between metformin use and the risk of age-related macular degeneration in patients with type 2 diabetes: a retrospective study.

ABSTRACT:

Objectives

To investigate the effect of metformin on the decreased risk of developing age-related macular degeneration (AMD) in patients with type 2 diabetes mellitus (T2DM) for ≥10 years.

Design

A retrospective study.

Participants

Patients aged ≥50 with a diagnosis of T2DM no less than 10 years were included.

Methods

Variables predisposing to AMD were reviewed; the potential confounders related to T2DM or AMD were selected from literature records; AMD and diabetic retinopathy (DR) were diagnosed by funduscopy, optical coherence tomography and/or fluorescein angiography. The subgroup analysis was performed in early and late AMD. The protective effect of metformin was evaluated in duration-response and dose-response patterns.

Results

A total of 324 patien

SUBMITTER: Jiang J 

PROVIDER: S-EPMC9045056 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature