Inflammatory Endotype-Associated Airway Resistome in Chronic Obstructive Pulmonary Disease.

ABSTRACT: Antimicrobial resistance is a global concern in chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD). The collection of antibiotic resistance genes or resistome in human airways may underlie the resistance. COPD is heterogeneous, and understanding the airway resistome in relation to patient phenotype and endotype may inform precision antibiotic therapy. Here, we characterized the airway resistome for 94 COPD participants at stable disease. Among all demographic and clinical factors, patient inflammatory endotype was associated with the airway resistome. There were distinct resistome profiles between patients with neutrophilic or eosinophilic inflammation, two primary inflammatory endotypes in COPD. For neutrophil-predominant COPD, the resistome was dominated

SUBMITTER: Yi X 

PROVIDER: S-EPMC9045194 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature